病例报告:患者男,71岁,上腹部胀痛2年余,近期加重,于1998年2月行纤维胃镜检查。胃镜所见:胃粘膜无明显异常,十二指肠球部粘膜水肿充血,前壁见1.5cm×1.2cm溃疡,溃疡深约0.3cm,边缘整齐,稍隆起,底部凸凹不平,表面附少量白苔。胃镜诊断:十二指肠球部:溃疡。取活组织3粒送病理检查。光镜所见:十二指肠粘膜糜烂坏死缺损,残存之绒毛增粗,固有膜内血管增生,嗜中性多形核白细胞,淋巴细胞、浆细胞浸润。粘膜内腺体增生,管腔大小不一,排列尚整,无明显异形。同一腺腔内部分腺上皮呈卵丘样增生,层次增多,排列紊乱,细胞核显著增大,染色质粗糙,核仁明显,可见较多病理性核分裂象。有些异形细胞突破腺腔基 Case report: The patient was male, 71 years old, with pain in his upper abdomen for more than 2 years. He was recently aggravated and he underwent gastroscopy in February 1998. Gastroscope findings: no abnormal gastric mucosa, duodenal mucosal edema, congestion, anterior wall see 1.5cm 1.2cm ulcers, ulcers about 0.3cm deep, neat edges, slightly bulging, uneven bottom, with a small amount of white surface moss. Endoscopic diagnosis: Duodenal bulb: ulcer. Take 3 biopsy tissue for pathological examination. Light microscopy revealed: duodenal mucosal necrosis and necrosis, residual villus thickening, proliferative vascular proliferation, neutrophil polymorphonuclear leukocyte, lymphocyte, and plasma cell infiltration. Intramucosal glandular hyperplasia, lumen size, alignment is still intact, no obvious shape. In the same glandular cavity, part of the glandular epithelium showed cumulus-like hyperplasia, increased levels, disordered arrangement, significantly increased nuclei, rough chromatin, and obvious nucleoli, showing more pathological mitotic figures. Some alien cells break through the cavity