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目的:系统评价survivin的表达与涎腺腺样囊性癌(SACC)的临床病理特征之间的相关性。方法:计算机检索PubMed、Embase、Cochrane Library、web of science、OVID、Springerlink、中国学术期刊全文数据库(CNKI)、中国生物医学数据库(CBM)、万方、重庆维普等数据库。根据各研究间的异质性,采用固定或随机效应模型合并比值比(ORs)和相应的95%可信区间(CIs),分析survivin表达与SACC的关联。结果:共纳入10个病例对照研究,包括367例SACC患者及124例正常对照。Meta分析结果显示:survivin在SACC组织中高表达(OR=38.26,95%CI:17.37~84.29,P<0.01),还与病理分型(OR=0.3,95%CI:0.17~0.55,P<0.01)、临床分期(OR=0.23,95%CI:0.13~0.42,P<0.01)以及淋巴结转移(OR=3.7,95%CI:1.82~7.56,P<0.01)有关,差异有统计学意义。结论:survivin的表达可能与SACC临床病理特征相关,但受纳入文献数量及质量的影响,尚需累积大样本高质量的研究来进一步证实。
OBJECTIVE: To systematically evaluate the correlation between the expression of survivin and clinicopathological features of salivary adenoid cystic carcinoma (SACC). Methods: The databases of PubMed, Embase, Cochrane Library, web of science, OVID, Springerlink, CNKI, CBM, Wanfang and Chongqing VIP were searched by computer. The association of survivin expression with SACC was analyzed based on heterogeneity among studies using odds ratios (ORs) and corresponding 95% confidence intervals (CIs) using either fixed or random effects models. Results: A total of 10 case-control studies were included, including 367 SACC patients and 124 normal controls. Meta analysis showed that survivin was highly expressed in SACC tissues (OR = 38.26, 95% CI: 17.37-84.29, P <0.01), and also correlated with the pathological type (OR = 0.3, 95% CI: 0.17-0.55, P <0.01) ), Clinical stage (OR = 0.23, 95% CI: 0.13-0.42, P <0.01) and lymph node metastasis (OR = 3.7,95% CI: 1.82-7.56, P <0.01). The difference was statistically significant. CONCLUSIONS: The expression of survivin may be related to the clinicopathological features of SACC. However, due to the quantity and quality of the included literature, it is still necessary to accumulate a large sample of high-quality studies to further confirm.