序言自从Bordet-gengon氏发现百日咳嗜血性杆菌以来,历时已50年(1906-1957年),百日咳对儿童健康危害的严重性已引起世界各国临床学家的重视,从事于细菌免疫学上的各种特异性预防与治疗的研究已不遗余力,但迄今已半世纪对百日咳的特异性预防问题尚未得到解决。百日咳不仅在临床上,有卡他期诊断困难和飞沫传染等特点,在细菌学上也有与其他细菌不同的特点,而形成了预防问题上许多困难。最近在细菌学上根据教授的研究,阐明了百日咳杆菌含有内外两 Preamble Since Bordet-gengon’s discovery of Bordetella pertussis has lasted for 50 years (1906-1957), the seriousness of whooping cough on the health of children has drawn the attention of clinicians from all over the world and engaged in various aspects of bacterial immunology Research on species-specific prevention and treatment has spared no effort, but so far the problem of pest-specific prevention has been unresolved for half a century. Pertussis not only in clinical, there are difficulties in diagnosis of catarrhal and droplets infection, bacteriological characteristics also have different from other bacteria, and formed a lot of prevention problems. Recent bacteriological studies based on professors have clarified that B. pertussis contains both internal and external