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[目的]探讨抗环瓜氨酸肽抗体在类风湿关节炎中的应用价值。[方法]采用酶联免疫吸附试验(ELISA)检测40例类风湿关节炎患者的血清抗环瓜氨酸肽抗体。[结果]类风湿关节炎组血清抗环瓜氨酸肽抗体水平明显高于其他组,且与RF-IgM有良好的相关性(P﹤0.05),血清抗环瓜氨酸肽抗体阳性者骨侵蚀较严重(P﹤0.01),经治疗后抗环瓜氨酸肽抗体水平下降(P﹤0.05)。[结论]抗环瓜氨酸肽抗体在类风湿关节炎的早期诊断、预后及疗效观察具有应用价值。
[Objective] To investigate the value of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis. [Methods] Serum anti-cyclic citrullinated peptide antibody was detected in 40 patients with rheumatoid arthritis by enzyme-linked immunosorbent assay (ELISA). [Results] The serum levels of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis group were significantly higher than those in the other groups (P <0.05), and the serum anti-cyclic citrullinated peptide antibody positive bone (P <0.01). The anti-cyclic citrullinated peptide antibody level decreased after treatment (P <0.05). [Conclusion] The anti-cyclic citrullinated peptide antibody has the application value in the early diagnosis, prognosis and curative effect of rheumatoid arthritis.