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小儿白血病在小儿恶性肿瘤中占第一位,占所有的恶性肿瘤的1/3左右。通过新的抗癌药物的应用,小儿白血病的存活率明显提高。我们用去甲氧柔红霉素联合方案治疗2例小儿白血病(1例急性早幼粒细胞白血病和1例难治性急性淋巴细胞性白血病)。结果提示:去甲氧柔红霉素治疗小儿白血病疗效确切,对心脏的毒性小于柔红霉素,但骨髓抑制比柔红霉素更加严重,通常需要加强支持疗法,如给予惠尔血、成分输血、静注大剂量丙种球蛋白等
Pediatric leukemia in children with malignant tumors in the first place, accounting for about 1/3 of all malignant tumors. Through the application of new anti-cancer drugs, the survival rate of childhood leukemia was significantly improved. We treated 2 patients with childhood leukemia (1 case of acute promyelocytic leukemia and 1 case of refractory acute lymphocytic leukemia) with a combination of methicillin-daunorubicin. The results suggest that daunorubicin is effective in the treatment of pediatric leukemia and its toxicity to the heart is less than that of daunorubicin. However, myelosuppression is more severe than daunorubicin, and usually needs to be strengthened with supportive therapy. For example, Transfusion, intravenous high-dose gamma globulin