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目的：观察α－黑素细胞刺激素（α－ＭＳＨ）拮抗剂［Ｄ－Ｔｒｐ７，Ａｌａ８，Ｄ－Ｐｈｅ１０］α－ＭＳＨ（６－１１）－ａｍｉｄｅ对家兔内毒素（ＥＴ）及肿瘤坏死因子（ＴＮＦ）性发热的影响。方法：侧脑室给药，ＳＴ－１型数字温度计测家兔的结肠温度。结果：（１）静脉注射ＥＴ，家兔体温呈典型的双相热；若事先侧脑室注射α－ＭＳＨ拮抗剂，则体温升高更明显，且热程明显延长，６ｈ体温反应指数（ＴＲＩ６）显著高于ＮＳ＋ＥＴ组（Ｐ＜０．０１）。（２）侧脑室注射ＴＮＦ－α引起体温明显升高；事先给予α－ＭＳＨ拮抗剂，则显著增强ＴＮＦ－α性发热效应（Ｐ＜０．０１）。而α－ＭＳＨ拮抗剂对正常体温无影响。结论：内源性解热物质α－ＭＳＨ在限制发热中发挥了重要作用。
Objective: To observe the effects of α-MSH (6-11) -amide, an α-melanocyte stimulating hormone (α-MSH) antagonist, on endotoxin and tumor necrosis factor (TNF) fever. Methods: Intracerebroventricular administration, ST-1 digital thermometer to measure the colonic temperature in rabbits. The results showed that: (1) The intravenous injection of ET showed typical biphasic heat in rabbits; if the intracerebroventricular injection of α-MSH antagonist was used, the body temperature rose more obviously and the heat process was prolonged. The temperature response index (TRI6) Significantly higher than NS + ET group (P <0.01). (2) Intracerebroventricular injection of TNF-α caused a significant increase in body temperature; pretreatment with α-MSH antagonist significantly enhanced TNF-α-induced fever (P <0.01). However, α-MSH antagonists have no effect on normal body temperature. Conclusion: The endogenous antipyretic substance α-MSH plays an important role in limiting fever.