论文部分内容阅读
Mosl of anticancer drugs are mutagenic. A possible exeeption is diallyl .trisulfide(DAT ), a component of garlic. It is an antimutagenic anticunccr chemical although it ismainly uscd as antibiotic. Its modifying effeci on induction of UDS by mutagenicmitomycin C (MMC), cyclophosphamide (CP) and cis-diamine dichloroplatin (DDP) was invcstigiltcd with the UDS assay in the primary cultures of Wistar rat hepatocytes (hpc)using the autoradiographic technique. Resultsshowed that 1.0-4.0 nmol/ml of DAT didnot inducc UDS and that MMC, CP and DDP resulted in a significant induction ofdosc-dependent UDS. DAT enhanced induction of UDS by these drugs. A dose-effectrclationship was observed betwecn dose of DAT and enhancement of induction of UDS.Howcvcr, thc mcchanism of the enhancement is not clear.
It is an antimutagenic anticunccr chemical although it ismainly uscd as antibiotic. Its modifying effeci on induction of UDS by mutagenic mitomycin C (MMC), A possible exeption is diallyl .trisulfide (DAT), a component of garlic. cyclophosphamide (CP) and cis-diamine dichloroplatin (DDP) was invcstigated with the UDS assay in the primary cultures of Wistar rat hepatocytes (hpc) using the autoradiographic technique. Results showed that 1.0-4.0 nmol / ml of DAT didnot inducc UDS and that MMC , CP and DDP resulted in a significant induction ofdosc-dependent UDS. D Amplified-effectrclationship was observed betweeen dose of DAT and enhancement of induction of UDS. Howcvcr, thc mcchanism of the enhancement is not clear .