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采用辐射聚合方法制备了聚N-异丙基丙烯酰胺(PNIPA)均聚物、N?异丙基丙烯酰胺(NIPA)与甲基丙烯酸2?羟基乙酯(HEMA)共聚物(P(NIPA?co?HEMA))和PNIPA/P(HEMA)互穿网络(InterpenetratingPolymerNetwork,IPN)水凝胶。研究了水凝胶溶胀度的温度依赖性;讨论了剂量率和吸收剂量对辐射聚合的影响,单体浓度及其配比和聚合介质对水凝胶的相转变温度、溶胀度和溶胀?消溶胀动力学的影响;并以木瓜蛋白酶作为模型药物,对水凝胶进行药物释放测定。实验结果表明,较为适宜的水凝胶在剂量率1kGy/h,吸收剂量30—40kGy,单体浓度10%和聚合介质正丁醇中辐射合成。此类共聚与互穿网络水凝胶适用于药物的可控释放。
Poly (N-isopropylacrylamide) (PNIPA) homopolymer, NIPA and HEMA copolymer (P (NIPA) co HEMA) and PNIPA / P (HEMA) Interpenetrating Polymer Network (IPN) hydrogels. The temperature dependence of swelling degree of hydrogel was studied. The effects of dose rate and absorbed dose on the radiation polymerization were discussed. The monomer concentration and its ratio and the phase transition temperature, swelling degree and swelling ratio Swelling kinetics; and papain as a model drug, the hydrogel for drug release determination. The experimental results show that the more suitable hydrogels are synthesized by radiation at a dose rate of 1 kGy / h, an absorbed dose of 30-40 kGy, a monomer concentration of 10% and a polymerization medium of n-butanol. Such copolymerized and interpenetrating network hydrogels are suitable for the controlled release of drugs.