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In the recent decades,the incidence of hepatocellularcarcinoma(HCC)has been found to be increasing in malesin some countries.In China,HCC ranked second of cancermortality since 1990s.Hepatitis B and C viruses(HBV andHCV)and dietary aflatoxin intake remain the majorcausative factors of HCC.Surgery plays a major role inthe treatment of HCC,particularly for small HCC.Down-staging unresectable huge HCC to smaller HCC andfollowed by resection will probably be a new approach forfurther study.Liver transplantation is indicated for smallHCC,however,some issues remain to be solved.Different modes of“regional cancer therapy for HCC”havebeen tried.Systemic chemotherapy has beendisappointing in the past but the future can be promising.Biotherapy,such as cytokines,differentiation inducers,anti-angiogenic agents,gene therapy and tumor vaccinewill probably play a role,particularly in the prevention oftumor recurrence.HCC invasiveness is currently themajor target of study.Tremendous works have been doneat the molecular level,which will provide clues forbiomarker of HCC progression as well as targets forintervention.
In the recent decades, the incidence of hepatocellular carcinoma (HCC) has been found to be increased in malesin some countries.In China, HCC ranked second of cancermortality since 1990s. Hepatitis B and C viruses (HBV and HCV) and dietary aflatoxin access remain the major causative Factors of HCC.Surgery plays a major role inthe treatment of HCC, specifically for small HCC.Down-staging unresectable huge HCC to smaller HCC andfollowed by resection will probably be a new approach forfurther study.Liver transplantation is indicated for smallHCC,however,some Resolveds to be solved.Different modes of“regional cancer therapy for HCC”havebeen tried.Systemic chemotherapy has beendisappointing in the past but the future can be promising.Biotherapy,such as cytokines,differentiation inducers,anti-angiogenic agents,gene Therapy and tumor vaccinewill probably play a role, specifically in the prevention of tumor recurrence.HCC invasiveness is currently themajor target of study.Tremendous works have been Doneat the molecular level, which will provide clues for biomarker of HCC progression as well as targets forintervention.