肾小球疾病是引起慢性肾脏疾病与终末期肾脏疾病的重要原因。构成肾小球的三大固有细胞包括系膜细胞(mesangial cell,MC)、足细胞及内皮细胞,它们各自对损伤机制产生的不同反应决定了肾小球损伤的不同病理类型,包括增生、分化、肥大、老化、凋亡及坏死,而这些反应类型又取决于 Glomerular disease is an important cause of chronic kidney disease and end-stage renal disease. The three innate cells that make up the glomerulus include mesangial cells (MCs), podocytes, and endothelial cells, each of which responds differently to the mechanism of injury that determines the different pathological types of glomerular injury, including proliferation, differentiation , Hypertrophy, aging, apoptosis and necrosis, which in turn depend on the type of reaction