A new homocoupling methodology mediated by a novel combination of CuCl-2,2’-dipyridyl and its application to the synthesis of substituted polyfluorinated alka-2,4-dienes are described. A new homocoupling methodology mediated by a novel combination of CuCl-2,2’-dipyridyl and its application to the synthesis of substituted polyfluorinated alka-2,4-dienes are described.