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目的研究HIV/AIDS患者外周血血常规检测指标与CD4+、CD8+淋巴细胞的相关性,寻求简易、廉价、高效、稳定的艾滋病病程的监测指标。方法采用回归分析等方法对282份HIV/AIDS患者血样白细胞(WBC)、淋巴细胞计数(W-SCC)、中性粒细胞计数(W-LCC)、红细胞(RBC)、血红蛋白浓度(HGB)、血小板(PLT)和CD4+、CD8+淋巴细胞数的相关性进行研究。结果 HIV/AIDS患者中血常规指标异常率较高,主要检测指标均在参考值范围内的仅占32.98%。HIV/AIDS患者血中WBC、W-SCC、W-LCC、RBC、HGB、PLT指标与CD4+淋巴细胞的相关关系均有统计学意义,相关系数分别为0.359、0.499、0.138、0.172、0.121、0.150。用W-SCC(x)估算CD4+淋巴细胞计数(y)的方程为y=101.32x+122.02。结论 HIV/AIDS患者淋巴细胞计数指标与CD4+淋巴细胞相关性较强,可以将其作为反映HIV/AIDS患者机体免疫状况及疾病发展阶段的一个重要指标。
Objective To study the correlation between peripheral blood blood test indicators and CD4 +, CD8 + lymphocytes in HIV / AIDS patients and to find a simple, inexpensive, efficient and stable indicator of AIDS course. Methods The levels of WBC, W-SCC, W-LCC, RBC, HGB, HbAb in 282 HIV / AIDS patients were determined by regression analysis and other methods. Platelet (PLT) and CD4 +, CD8 + lymphocyte numbers were studied. Results The abnormal rate of blood routine indicators was higher in HIV / AIDS patients, with only 32.98% of the major test indicators in the reference range. The correlation of WBC, W-SCC, W-LCC, RBC, HGB, PLT and CD4 + lymphocytes in HIV / AIDS patients were statistically significant with correlation coefficients of 0.359, 0.499, 0.138, 0.172, 0.121 and 0.151 . The equation for estimating CD4 + lymphocyte count (y) with W-SCC (x) is y = 101.32x + 122.02. Conclusion The lymphocyte counts of HIV / AIDS patients are highly correlated with CD4 + lymphocytes, which may be used as an important index to reflect the immune status of HIV / AIDS patients and the stage of disease development.