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目的:定量检测糖皮质激素受体-α(GR-α)mRNA在鼻息肉和鼻腔正常黏膜中的表达,并探讨其在鼻息肉发生发展中的意义。方法:采用荧光定量逆转录PCR(FQ-RT-PCR)检测36例鼻息肉(息肉组)和31例鼻腔正常黏膜(对照组)中GR-αmRNA定量表达。结果:GR-α在对照组[(135.4±5.2)×1010copy/g]中比息肉组[(25.5±5.0)×1010copy/g]中表达高,两组之间差异有统计学意义(P<0.01)。结论:GR-α在息肉组织中的低表达,可能是促进鼻息肉发生发展的一个重要因素。
Objective: To quantitatively detect the expression of glucocorticoid receptor-α (GR-α) mRNA in nasal polyps and nasal mucosa and to explore its significance in the development of nasal polyps. Methods: The quantitative expression of GR-αmRNA in 36 cases of nasal polyp (polyp group) and 31 cases of normal nasal mucosa (control group) were detected by fluorescence quantitative reverse transcription PCR (FQ-RT-PCR) Results: The expression of GR-α in the control group [(135.4 ± 5.2) × 1010copy / g] was higher than that in the polyp group [(25.5 ± 5.0) × 1010copy / g], with significant difference between the two groups (P < 0.01). Conclusion: The low expression of GR-α in polyp tissues may be an important factor to promote the development of nasal polyps.