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目的探讨脱氧核苷酸钠注射液联合干扰素治疗慢性乙型肝炎的临床疗效。方法选取浚县人民医院2015年1月—2016年1月收治的慢性乙型肝炎患者120例,随机分成观察组与对照组,各60例。观察组患者给予脱氧核苷酸钠注射液联合干扰素治疗,对照组患者给予干扰素治疗,比较两组患者治疗前后丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)及乙肝e抗体(抗HBe)阳转率、乙肝表面抗原(HBe Ag)阴转率、乙肝病毒的脱氧核糖核酸(HBVDNA)转阴率。结果治疗前两组患者ALT、AST比较,差异无统计学意义(P>0.05);治疗后观察组ALT、AST低于对照组,差异有统计学意义(P<0.05)。观察组HBe Ag阴转率、抗HBe阳转率、HBVDNA阴转率高于对照组,差异有统计学意义(P<0.05)。结论脱氧核苷酸钠注射液联合干扰素治疗慢性乙型肝炎的临床疗效确切,可有效改善患者的肝功能,提高患者生活质量。
Objective To investigate the clinical efficacy of deoxynucleotide sodium injection combined with interferon in the treatment of chronic hepatitis B patients. Methods 120 patients with chronic hepatitis B who were admitted to Junxian People’s Hospital from January 2015 to January 2016 were randomly divided into observation group and control group, 60 cases each. Patients in the observation group were treated with dexcyanate injection combined with interferon and control patients were treated with interferon. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) And hepatitis B e antibody (anti-HBe) positive rate, hepatitis B surface antigen (HBeAg) negative rate, hepatitis B virus DNA (HBVDNA) negative rate. Results There was no significant difference in ALT and AST between the two groups before treatment (P> 0.05). After treatment, the ALT and AST in the observation group were lower than those in the control group (P <0.05). The negative rate of HBe Ag, anti-HBe positive rate and HBVDNA negative rate in the observation group were significantly higher than those in the control group (P <0.05). Conclusion Sodium deoxyribonucleotide injection combined with interferon in the treatment of chronic hepatitis B has definite curative effect, which can effectively improve the liver function and improve the quality of life of patients.