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Lewis X(Le~x)、唾液酸化的Lewis X(Sialyl Lewis X,SLe~x)和唾液酸化的双岩藻糖Lewis X(Sialyl Dimeric Lewis X,SDLe~x)是细胞表面外侧带α1,3岩藻糖的糖链结构。本文用免疫组化ABC法研究了肺癌原发灶、转移灶和癌旁组织中这三种抗原结构的表达。结果发现这三种抗原在肺癌细胞表面及胞浆中均有不同程度的表达,而在肺癌癌旁组织及正常肺组织中未见表达。有转移的肺癌和(或)低分化肺癌中这三种抗原结构的表达要明显高于未发生转移和高、中分化肺癌中相同抗原结构的表达。其中以SLe~x的表达与肺癌细胞的转移能力和分化程度关系最为密切。另外,肺癌浸润转移的淋巴结中也有Le~x、SLe~x的明显表达和SDLe~x的少量表达,而未被肺癌浸润转移的淋巴结中就没有它们的表达。
Lewis X (Le~x), sialylated Lewis X (Sleyl Lewis X, SLe~x) and sialyled double fucose Lewis X (Sialyl Dimeric Lewis X, SDLe~x) are cell surface outer bands with alpha 1,3 rock The sugar chain structure of the sugar. In this study, we used immunohistochemical ABC method to study the expression of these three antigens in primary tumor, metastatic tumor and adjacent tissues of lung cancer. As a result, these three antigens were found to have different degrees of expression on the surface and in the cytoplasm of lung cancer cells, but no expression was observed in the lung cancer adjacent tissues and normal lung tissues. The expression of these three antigens in metastatic lung cancer and/or poorly differentiated lung cancer was significantly higher than that in non-metastatic and high- and moderately differentiated lung cancers. Among them, the expression of SLe~x is most closely related to the metastatic potential and differentiation of lung cancer cells. In addition, the lymph node infiltration and metastasis of lung cancer also showed significant expression of Le~x, SLe~x, and small expression of SDLe~x, but no expression of them was found in lymph nodes that were not infiltrated and metastasized by lung cancer.