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采用中国杂种家犬26只,结扎左冠状动脉5.15或30min后进行再灌注以及结扎与再灌注同时给予山莨菪碱治疗吋,心肌缺血-再灌注性心律失常(RA)及氧自由基的改变,以探讨缺血-再灌注性损伤的形成因素及防治。结果发现,RA的形成受到缺血范围的大小、侧支循环丰富与否、缺血时间长短、反复缺血次数等影响。使用山莨菪碱后室性自搏的发生显著减少(P<0.05),室速、室颤及ST段改变均较用药前明显减轻,甚至可使已经出现的Q波消失。用药后检测谷胱甘肽过氧化物酶(GSH-px)水平明显上升。证实该药对缺血-再灌注性损伤具有较好的防治作用。
Twenty - six Chinese domesticated dogs, ligation of the left coronary artery for 5.15 or 30 minutes followed by reperfusion, ligation and reperfusion with anisodamine, myocardial ischemia - reperfusion arrhythmia (RA) and oxygen free radicals , In order to explore the formation of ischemic-reperfusion injury and prevention and treatment. The results showed that the formation of RA by the size of the ischemic range, collateral circulation rich or not, the length of ischemia, the number of repeated ischemia and other effects. The incidence of ventricular spontaneous regression after anisodamine was significantly reduced (P <0.05). The changes of ventricular tachycardia, ventricular fibrillation and ST segment were significantly reduced compared with those before treatment, and Q waves that had appeared were disappeared. After treatment, the level of glutathione peroxidase (GSH-px) was significantly increased. Confirmed that the drug has a good preventive and therapeutic effect on ischemia-reperfusion injury.