用153Sm－sortan治疗48例癌症骨转移性疼痛二按29.6MBq／Kg计算治疗剂量，静脉注射。其中12例接受2—5次治疗，2次间隔4周。本组骨痛完全缓解18例，部分缓解21例，总有效率81．25％。缓解时间2—12周，镇痛疗效可能同原发肿瘤类型、骨转移病灶数量及大小相关。153Sm—EDTMP骨髓毒性低，但多次用药对骨髓毒性有剂量累积。 Treatment of 48 cases of metastatic bone pain with 153Sm-sortan was performed at a therapeutic dose of 29.6MBq/kg and intravenously. Twelve of these patients received 2 to 5 treatments, 2 at 4 week intervals. In this group, 18 cases of complete remission of bone pain, partial remission in 21 cases, the total effective rate of 81.25%. The remission time of 2-12 weeks, the analgesic effect may be related to the type of primary tumor, the number and size of bone metastases. 153Sm-EDTMP has low bone marrow toxicity, but multiple doses have a dose-accumulation of bone marrow toxicity.