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本文报告一例长期诊断为“慢性活动性肝炎”、“类风湿性关节炎”及“肺部感染”的混合结缔组织病(简称MCTD)。MCTD表现为两种以上结缔组织病的不完全混合(重叠),可累及除肾脏以外的全身器官;血清中可检出高效价抗RNP抗体,而无抗Sm抗体为其实验室特征;本病对糖皮质激素治疗反应较佳。我们认为MCTD是不同于重叠综合征和系统性红斑狼疮的一种独立的结缔组织疾病。
This article reports a case of mixed connective tissue disease (MCTD) diagnosed chronically for “chronic active hepatitis”, “rheumatoid arthritis” and “lung infection.” MCTD is manifested as incomplete mixing (overlap) of two or more connective tissue diseases that can affect whole body organs other than the kidneys; high-titer anti-RNP antibodies can be detected in serum without anti-Sm antibodies as their laboratory characteristics; Good response to glucocorticoid treatment. We believe that MCTD is an independent connective tissue disease that differs from overlapping syndromes and systemic lupus erythematosus.