目的:观察头孢唑肟钠治疗慢性支气管炎急性发作的临床应用价值。方法:选取我院2010年12月-2011年12月期间收治的72例慢性支气管炎急性发作患者,按每组36例随机分为A、B两组。给予A组患者头孢他啶治疗,给予B组患者头孢唑肟钠治疗,对比两组患者临床治疗效果。结果:A组患者总治疗有效率为77.8%,B组患者总治疗有效率为91.7%。两组患者治疗效果对比,B组患者更佳,差异显著具有统计学意义(P<0.05)。A、B两组患者咳嗽消失时间、呼吸恢复正常时间、湿罗音消失时间对比,B组患者临床症状消失时间更短,差异显著具有统计学意义(P<0.05)。两组患者临床治疗期间均未发现明显不良反应,对两组患者肝、肾等器官功能进行检查,未发现明显异常现象。结论:头孢唑肟钠治疗慢性支气管炎急性发作临床应用效果显著,安全性高,值得临床推广与应用。 Objective: To observe the clinical value of ceftizoxime sodium in the treatment of acute exacerbation of chronic bronchitis. Methods: Seventy-two patients with acute exacerbation of chronic bronchitis admitted from December 2010 to December 2011 in our hospital were randomly divided into A and B groups. Patients in group A were treated with ceftazidime, and patients in group B were treated with ceftizoxime sodium. The clinical effects were compared between the two groups. Results: The total effective rate of treatment in group A was 77.8%, and the total effective rate in group B was 91.7%. The two groups of patients with treatment effect comparison, B group patients better, the difference was statistically significant (P <0.05). The disappearance time of cough, respiration normal time and the disappearance time of wet rales in groups A and B were shorter than those in group B, and the disappearance time of clinical symptoms in group B was shorter, with significant difference (P <0.05). No significant adverse reactions were found during the clinical treatment of the two groups. The liver, kidney and other organ functions were examined in both groups, and no obvious abnormalities were found. Conclusion: Ceftizoxime sodium in the treatment of acute exacerbation of chronic bronchitis has significant clinical application, high safety, and worthy of clinical promotion and application.