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目的:探讨卡托普利对急性肺损伤(ALI)大鼠血清TNF-α和IL-8的影响。方法:36只成年Wistar大鼠随机平均分为正常对照组、烟雾致伤组(ALI组)和卡托普利干预组(CAP组)。CAP组腹腔注射卡托普利(5 mg/kg),对照组和ALI组腹腔注射等量生理盐水。15 min后复制烟雾吸入性肺损伤模型。致伤后5 min、5 h采动脉血行血气分析,致伤后5 h检测血清TNF-α、IL-8浓度。结果:ALI组血清TNF-α、IL-8含量明显高于正常对照组(P<0.01)。CAP组血清IL-8含量显著低于ALI组(P<0.05),动脉血气明显改善,TNF-α两者无显著差异(P>0.05)。结论:卡托普利能降低ALI大鼠血清IL-8浓度,对TNF-α无显著影响。
Objective: To investigate the effect of captopril on serum TNF-α and IL-8 in acute lung injury (ALI) rats. Methods: Thirty-six adult Wistar rats were randomly divided into normal control group, smoke-induced injury group (ALI group) and captopril intervention group (CAP group). Captopril (5 mg / kg) was injected intraperitoneally in CAP group, and normal saline in control group and ALI group. Fifteen minutes later, smoke-induced lung injury model was duplicated. Blood samples were taken at 5 min after injury and blood samples were collected at 5 h after injury. Serum levels of TNF-α and IL-8 were detected 5 h after injury. Results: The levels of serum TNF-α and IL-8 in ALI group were significantly higher than those in normal control group (P <0.01). The level of serum IL-8 in CAP group was significantly lower than that in ALI group (P <0.05), arterial blood gas was significantly improved, and there was no significant difference in TNF-α (P> 0.05). Conclusion: Captopril can reduce the concentration of serum IL-8 in ALI rats, but have no significant effect on TNF-α.