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目的探讨氨基末端-脑钠肽前体(N-terminal pro brain natriuretic peptide,NT-proBNP)在急性呼吸困难中的鉴别诊断价值。方法用电化学发光免疫法(ECLIA)测定170例急性呼吸困难患者血浆NT-proBNP,包括心力衰竭性呼吸困难和非心源性呼吸困难,观察两种急性呼吸困难患者血浆NT-proBNP的浓度。结果充血性心力衰竭(CHF)引起的急性呼吸困难患者NT-proBNP浓度明显高于非CHF组患者(P<0.01);CHF组NT-proBNP浓度在心功能不同级别间差异有统计学意义,与左室射血分数(LVEF)呈负相关。结论NT-proBNP水平可以作为诊断心力衰竭的一个很好的指标;是鉴别心源性呼吸困难患者的敏感和特异的观察指标。
Objective To investigate the differential diagnosis value of N-terminal pro brain natriuretic peptide (NT-proBNP) in acute dyspnea. Methods Plasma NT-proBNP levels were measured in 170 patients with acute dyspnea using electrochemiluminescence immunoassay (ECLIA), including heart failure dyspnea and noncardiogenic dyspnea. Plasma concentrations of NT-proBNP were measured in two patients with acute dyspnea. Results The concentration of NT-proBNP in patients with acute dyspnea induced by congestive heart failure (CHF) was significantly higher than that in non-CHF patients (P <0.01). The NT-proBNP concentration in CHF patients was significantly different between different levels of cardiac function, Room ejection fraction (LVEF) was negatively correlated. Conclusion The level of NT-proBNP can be used as a good indicator to diagnose heart failure. It is a sensitive and specific observation index for identifying patients with cardiogenic dyspnea.