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目的研究核因子-κB(NF-κB)在直肠癌组织中的表达及其与肿瘤细胞分化、浸润、淋巴结转移及远处转移等生物学行为的关系。方法应用Envision二步法检测60例直肠癌及30例癌旁组织石蜡标本中NF-κBp65蛋白的表达水平。结果 NF-κB在癌组织的表达明显高于癌旁组织,低分化癌组织较高分化、中分化组织中NF-κB的表达高;有淋巴结转移的组织较无转移的表达高;浸润程度越深,表达越高;有远处转移的组织较无转移的表达高。结论 NF-κBp65蛋白在直肠癌中有高表达,并且其在直肠癌的发生、转移过程中发挥重要作用,可能成为直肠癌治疗的一个新靶点。
Objective To investigate the expression of nuclear factor-κB (NF-κB) in rectal cancer and its relationship with the biological behavior of tumor cells such as differentiation, invasion, lymph node metastasis and distant metastasis. Methods Envision two-step method was used to detect the expression of NF-κBp65 protein in 60 cases of rectal cancer and 30 cases of para-cancerous tissues. Results The expression of NF-κB in cancer tissues was significantly higher than that in adjacent non-cancerous tissues. The expression of NF-κB in well-differentiated and differentiated tissues of poorly differentiated carcinoma tissues was higher than that in non-metastatic tissues. The degree of infiltration was higher Deep, the higher the expression; distant metastasis than the high expression of non-metastasis. Conclusion NF-κBp65 protein is highly expressed in rectal cancer and plays an important role in the carcinogenesis and metastasis of rectal cancer and may be a new therapeutic target for rectal cancer.