论文部分内容阅读
目的:分析雷公藤多苷联合环磷酰胺治疗肾病综合征的临床疗效,为临床寻求新的治疗方法提供参考依据。方法:选择60例肾病综合征患者为研究对象,按照治疗方法的不同分为两组,每组30例;其中给予雷公藤多苷联合环磷酰胺治疗的为观察组,单用环磷酰胺治疗的为对照组。观察记录两组患者的临床疗效以及不良反应情况,并进行分析比较。结果:经过治疗,观察组患者显效18例,有效10例,无效2例,出现不良反应3例,所有不良反应未经特殊处理自行缓解;对照组患者显效9例,有效11例,无效10例,出现不良反应10例,停药处理后患者不良反应自行缓解,未出现其它严重不良反应。两组总有效率、不良反应情况比较差异均具有统计学意义(P<0.05)。结论:雷公藤多苷联合环磷酰胺治疗肾病综合征疗效优于单一药物治疗,不良反应少,值得临床推广和使用。
OBJECTIVE: To analyze the clinical efficacy of tripterygium glycosides combined with cyclophosphamide in the treatment of nephrotic syndrome and to provide a reference for clinical seeking new treatment methods. Methods: Sixty patients with nephrotic syndrome were selected as the study subjects and divided into two groups according to the different treatment methods, 30 cases in each group. The patients in the treatment group were treated with tripterygium glycosides combined with cyclophosphamide and treated with cyclophosphamide alone For the control group. Observed and recorded the clinical efficacy and adverse reactions of two groups of patients, and analyzed and compared. Results: After treatment, the observation group of patients markedly effective in 18 cases, effective in 10 cases, 2 cases of ineffective, 3 cases of adverse reactions, all adverse reactions without special treatment to ease; control group of patients markedly effective in 9 cases, effective in 11 cases, ineffective in 10 cases , There were 10 cases of adverse reactions, patients with ADHD after treatment to ease their own side effects, no other serious adverse reactions. The two groups of total effective rate, adverse reactions were statistically significant differences (P <0.05). Conclusion: Tripterygium glycosides combined with cyclophosphamide in the treatment of nephrotic syndrome is superior to single drug therapy, with less adverse reactions, which is worthy of clinical promotion and use.