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目的:对比分析3D打印模板联合CT引导n 125I粒子植入治疗骨转移癌术前术后常用剂量学指标差异,指导临床应用。n 方法:对2019年6月至2021年1月天津市第三中心医院骨转移癌粒子植入手术的10例患者共12个病灶进行回顾性分析,12个病灶均采用3D打印模板引导粒子植入,处方剂量120~140 Gy,比较术前治疗计划及术后验证计划中常用剂量学指标差异,包括n D90、n D100、n V90、n V100、n V150以及术前计划粒子数量和术后实际使用粒子数量,采用配对n t检验对术前术后剂量参数进行对比分析。n 结果:术前和术后n D90、n D100、n V90、n V100、n V150等剂量学指标差异均无统计学意义(n P>0.05),术后实际使用粒子数量多于术前计划,差异有统计学意义(n t=-2.930, n P 0.05). The actual quantity of seeds used after operation was more than that of the preoperative planned quantity and the difference was statistically significant ( n t=-2.930, n P < 0.05).n Conclusions:The clinical use of 3D-printing template assisted by CT-guided n 125I seed implantation for bone metastasis should be promoted since the dose is accurate and the requirements of preoperative plan can be achieved.n