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1980年藤原等用肺表面活性物质(PSF)治疗新生儿呼吸窘迫综合征(RDS)成功之后,在日本进行了广泛的协作研究。现将46个医疗单位,55例超未成熟儿的PSF治疗结果报告如下。一、早期疗效在55例超未成熟儿中,<750g的13例;≥750g而<1,000g的42例。治疗后6小时,Bomsel分类Ⅰ级以上的有效例为,<750g和≥750g而<1,000g组分别为62%和93%,可见前者疗效较差。24小时以后二者症状明显改善的则分别为90%和94%。治疗前换气指数(Ⅵ):<750g的为0.19±0.11;≥750g而<1,000g的为0.16±0.08;与≥1,000g者相比明显增高,重症RDS例
After the successful treatment of neonatal respiratory distress syndrome (RDS) with pulmonary surfactant (PSF) by Fujiwara et al in 1980, a wide range of collaborative studies were conducted in Japan. Now 46 medical units, 55 cases of ultra-immature children’s PSF treatment results are reported as follows. First, the early effect In 55 cases of immature infants, <750g in 13 cases;> 750g and <1,000g in 42 cases. Six hours after treatment, effective cases of grade I or higher of the Bomsel classification were <750 g and> 750 g and <1,000 g, respectively, with 62% and 93%, respectively. After 24 hours, the symptoms of both patients improved significantly to 90% and 94% respectively. The ventilatory index (Ⅵ) before treatment was 0.19 ± 0.11 for <750g and 0.16 ± 0.08 for <1000g, and was significantly higher than for> 1,000g, with severe RDS