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目的:进一步探讨左氧氟沙星在根除幽门螺杆菌治疗中的有效性和安全性。方法:治疗组给予枸橼酸铋雷尼替丁400mg、左氧氟沙星200mg、阿莫西林1000mg,每天2次,疗程10d;对照组给予枸橼酸铋雷尼替丁400mg、克拉霉素0.5g、阿莫西林1000mg,每天2次,疗程10d。停药4周后复查C14呼气试验。结果:治疗组根除55例,根除率91.67%;对照组根除52例,根除率86.67%;两组比较无统计学差异(P>0.05)。两组患者不良反应轻微,于停药后均消失,总体安全性好。结论:以枸橼酸铋雷尼替丁为基础的含左氧氟沙星三联方案根除幽门螺杆菌10d疗法根除率达91.67%,且不良反应轻微,同时10d疗程费用比对照组低廉,容易被患者接受,值得临床推广。
Objective: To further investigate the efficacy and safety of levofloxacin in the treatment of Helicobacter pylori eradication. Methods: The treatment group was given ranitidine bismuth citrate 400mg, levofloxacin 200mg, amoxicillin 1000mg twice daily for 10 days; the control group was given ranitidine bismuth citrate 400mg, clarithromycin 0.5g, Moxilin 1000mg, 2 times a day, treatment 10d. C14 breath test after 4 weeks withdrawal. Results: In the treatment group, 55 cases were eradicated, and the eradication rate was 91.67%. In the control group, 52 cases were eradicated, and the eradication rate was 86.67%. There was no significant difference between the two groups (P> 0.05). Adverse reactions in both groups were mild, disappeared after stopping, overall safety is good. Conclusion: The triple therapy with levofloxacin based on bismuth citrate could eradicate H. pylori eradication by 91.67% with minimal adverse reaction, and the 10-day course cost was lower than that of the control group and was easily accepted by patients Clinical promotion.