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目的观察脑梗死患者血液一氧化氮(NO)水平变化与颈动脉粥样硬化斑块形态的关系。方法 109例脑梗死患者根据颈动脉超声改变分为软斑块组、硬斑块组和无斑块组,并设23例对照组;测定4组总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、NO的浓度。结果 4组NO水平之间差异明显(P<0.05),软斑块组、硬斑块组和无斑块组NO水平低于对照组,软斑块组、硬斑块组NO水平低于无斑块组,软斑块组NO水平低于硬斑块组。结论一氧化氮可以在一定程度上反映颈动脉粥样硬化斑块的状态,可能与颈动脉粥样硬化斑块的性质有关。
Objective To observe the relationship between the level of blood nitric oxide (NO) and the morphology of carotid atherosclerosis plaque in patients with cerebral infarction. Methods One hundred and ninety-nine patients with cerebral infarction were divided into soft plaque group, hard plaque group and no plaque group according to the changes of carotid artery ultrasound. Twenty-three control subjects were divided into two groups. Total cholesterol, triglyceride, high density lipoprotein cholesterol , Low density lipoprotein cholesterol, NO concentration. Results The levels of NO in the four groups were significantly different (P <0.05). The levels of NO in the soft plaque group, the hard plaque group and the non-plaque group were lower than those in the control group. The levels of NO in the soft plaque group and the hard plaque group were lower than those in the control group Plaque group, soft plaque group NO level was lower than the hard plaque group. Conclusion Nitric oxide can reflect the state of carotid atherosclerotic plaque to some extent, which may be related to the nature of carotid atherosclerotic plaque.