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为了探讨遗传因素与慢性阻塞性肺部疾病（ＣＯＰＤ）之间的关系，进一步提高人们对ＣＯＰＤ的环境病因和遗传病因的认识，收集了２０６个ＣＯＰＤ核心家系的资料。分析结果表明，ＣＯＰＤ的分离比为０．２７，ＣＯＰＤ属于多基因遗传；ＣＯＰＤ的遗传度为４４．４％，其中男性为４９．３％，女性为３８．８％。显示遗传因素在男性产生ＣＯＰＤ的过程中作用较大；但不论男性还是女性发生ＣＯＰＤ，遗传因素和环境因素，同样都是ＣＯＰＤ发病的重要危险因素
To investigate the relationship between genetic factors and chronic obstructive pulmonary disease (COPD) and to further raise awareness of the environmental causes and genetic causes of COPD, data on 206 core family members of COPD were collected. The results showed that the COPD was 0.27 and COPD was polygenic. The heritability of COPD was 44.4%, of which 49.3% were male and 38.8% were female. It shows that genetic factors play a greater role in the development of COPD in men; however, COPD, genetic factors and environmental factors, whether male or female, are also important risk factors for the development of COPD