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The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1,3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety.The adducts were isolated with high enantiomeric excess(up to 99%).
The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1,3-dicarbonyl compounds with acyl imines to produce novel β-aminoester derivatives containing a quinazoline moiety. Adducts were isolated with high enantiomeric excess (up to 99%).