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目的:研究黏附蛋白E-cd及α-Cat在良恶性前列腺组织中的表达,以及能否作为判定前列腺癌(PCa)预后的标志物。方法:应用免疫组化Elivision法,检测10例前列腺增生(BPH)和45例PCa患者组织标本中E-cd及α-Cat表达,并探讨E-cd及α-Cat的表达与PCa分级、分期、术前PSA、内分泌治疗效果及预后的关系。结果:①E-cd表达情况:在PCa和BPH中异常表达率分别为86.7%和10.0%,差异有显著性(P<0.05);PCa中转移和未转移组、Gleason评分≤7和Gleason评分>7组E-cd异常表达率分别为85.0%和87.5%,100.0%和86.7%,组间比较差异无显著性(P>0.05);PSA≤10μg/L和PSA>10μg/L的PCa中E-cd异常表达率分别为40.0%和97.1%,组间比较差异有显著性(P<0.05);在内分泌治疗有效与无效组中E-cd异常表达率分别为93.8%和72.7%,组间比较差异无显著性(P>0.05)。②α-Cat表达情况:PCa和BPH中α-Cat异常表达率分别为93.3%和30.0%,差异有显著性(P<0.05);PCa中转移和未转移组、Gleason评分>7和Gleason评分≤7组α-Cat异常表达率为90.0%和100.0%,90.0%和100.0%,组间比较差异无显著性(P>0.05);PSA≤10μg/L和PSA>10μg/L的PCa中α-Ca异常表达率为40.0%和94.3%,两者比较差异有显著性(P<0.05);在内分泌治疗有效与无效组中α-Cat异常表达率表达分别为100.0%和81.8%,组间比较差异无显著性(P>0.05)。结论:E-cd和α-Cat的表达与前列腺组织良恶性有关,与PCa转移性无关,在PCa中E-cd和α-Cat表达与PSA值成负相关。
Objective: To investigate the expression of E-cadherin and α-Cat in benign and malignant prostatic tissues, as well as whether it can be used as a marker of prognosis of prostate cancer. Methods: The expression of E-cd and α-Cat in 10 benign prostatic hyperplasia (BPH) and 45 cases of PCa were detected by immunohistochemical Elivision method. The expressions of E-cd and α-Cat were compared with PCa grade, , Preoperative PSA, the effect of endocrine therapy and prognosis. Results: (1) The expression of E-cd: The abnormal expression rates in PCa and BPH were 86.7% and 10.0%, respectively, with significant difference (P <0.05); The Gleason score≤7 and Gleason score> The abnormal expression rates of E-cd in 7 groups were 85.0% and 87.5%, 100.0% and 86.7%, respectively. There was no significant difference between the two groups (P> 0.05) -CD were 40.0% and 97.1%, respectively. There was significant difference between the two groups (P <0.05). The abnormal expression rates of E-cd in effective and ineffective groups of endocrine therapy were 93.8% and 72.7% There was no significant difference (P> 0.05). ②α-Cat expression: The abnormal expression rates of α-Cat in PCa and BPH were 93.3% and 30.0%, respectively (P <0.05); The Gleason score> 7 and Gleason score ≤7 in metastasis and non-metastasis group The abnormal expression rates of α-Cat in 7 groups were 90.0% and 100.0%, 90.0% and 100.0%, respectively. There was no significant difference between the two groups (P> 0.05). In α-Cat of PSA≤10μg / L and PSA> 10μg / The abnormal expression rate of Ca was 40.0% and 94.3%, respectively, with significant difference (P <0.05). The abnormal expressions of α-Cat in effective and ineffective groups of endocrine therapy were 100.0% and 81.8%, respectively There was no significant difference (P> 0.05). Conclusions: The expressions of E-cd and α-Cat are related to benign and malignant prostatic tissues, but not PCa metastatic. The expression of E-cd and α-Cat in PCa is negatively correlated with PSA.