目的分析冠状动脉临界病变中冠状动脉血流储备分数(fractional flow reserve,FFR)≥0.75的相关因素。方法对304例冠状动脉临界病变患者进行FFR测定,依据FFR值将患者分为FFR≥0.75组192例和FFR<0.75组112例。比较2组患者临床资料,分析FFR≥0.75的预测因子。结果 FFR≥0.75组年龄[(62.67±8.90)岁]、女性比例(34.90%)、非左主干病变比例(93.75%)、陈旧性心肌梗死比例(17.19%)高于FFR<0.75组[(50.14±8.41)岁、20.54%、73.21%、5.36%],病变长度[(16.40±9.70)mm]低于FFR<0.75组[(23.70±12.30)mm],2组比较差异有统计学意义(P<0.05);logistic回归分析显示女性(OR=1.920,95%CI:1.234~2.987,P=0.010)、年龄(OR=1.348,95%CI:1.056~1.722,P=0.013)、陈旧性心肌梗死(OR=1.373,95%CI:1.146~1.649,P=0.012)、非左主干病变(OR=2.347,95%CI:1.988~5.573,P=0.001)、病变长度(OR=0.877,95%CI:0.532~0.904,P=0.017)为FFR≥0.75的预测因子。结论女性、高龄、陈旧性心肌梗死、非左主干病变、短病变是冠状动脉临界病变中FFR≥0.75的相关因素。 Objective To analyze the related factors of coronary flow in coronary artery (FFR) ≥0.75. Methods FFR was measured in 304 patients with critical coronary artery disease. According to FFR, 192 patients were divided into FFR≥0.75 and 112 patients with FFR <0.75. The clinical data of two groups were compared and the predictors of FFR≥0.75 were analyzed. Results The age of FFR≥0.75 group was significantly higher than that of FFR group [(62.67 ± 8.90)], female ratio (34.90%), non-left main coronary artery disease (93.75%) and old myocardial infarction group (17.19% ± 8.41) years old, 20.54%, 73.21% and 5.36%, respectively. The length of lesion was significantly lower than FFR <0.75 group [(23.70 ± 12.30) mm] <0.05). The logistic regression analysis showed that there was no significant difference in age (OR = 1.348, 95% CI: 1.056-1.722, P = 0.013), old myocardial infarction (OR = 1.373, 95% CI: 1.146-1.649, P = 0.012), non-left main disease (OR = 2.347,95% CI: 1.988-5.573, P = 0.001) : 0.532 ~ 0.904, P = 0.017) as predictors of FFR≥0.75. Conclusion Female, elderly, old myocardial infarction, non-left main trunk lesion and short lesion are the related factors of FFR≥0.75 in the critical coronary artery disease.