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在多囊卵巢综合征(PCOS)患者中应用促性腺激素促排卵可能导致卵巢过度刺激反应,最常见的为卵巢过度刺激综合征(OHSS)和多胎妊娠。研究发现使用甾体激素阻断剂可降低卵巢的反应性。用酮康唑——一种抗霉菌药且为P~(450)羟化酶抑制剂,能有效且可逆地减少卵巢合成甾体激素。 材料与方法:28例PCOS患者在促排卵过程中加用酮康唑,使用酮康唑前均测定肝转氨酶及胆红素水平,给药的最后1天复测肝功能。给药方法:①
The application of gonadotropin to ovulation in patients with polycystic ovary syndrome (PCOS) may lead to ovarian hyperstimulation reactions, most commonly OHSS and multiple pregnancies. The study found that the use of steroid hormone blockers can reduce ovarian reactivity. With ketoconazole, an antimycotic drug and a p ~ (450) hydroxylase inhibitor, can effectively and reversibly reduce ovarian steroid-producing hormones. MATERIALS AND METHODS: 28 cases of PCOS patients were treated with ketoconazole during ovulation induction. Liver transaminases and bilirubin levels were measured before ketoconazole administration. Liver function was measured on the last day of administration. Method of administration: ①