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目的探讨5%杀螺胺乙醇胺盐颗粒剂的制备方法及其杀螺效果。方法通过对润湿剂、分散剂、黏合剂和载体进行筛选,得出5%杀螺胺乙醇胺盐颗粒剂的最佳配方。将制得的氯硝柳胺乙醇胺盐颗粒剂进行堆密度、松密度、水分和热储稳定性评价,调查5%杀螺胺乙醇胺盐颗粒剂喷撒法的实验室和现场杀螺效果。结果5%杀螺胺乙醇胺盐颗粒剂的最佳配方和制备方法为:5%的杀螺胺乙醇胺盐、0.2%的十二烷基硫酸钠、1%的烷基酚聚氧乙烯基醚磺酸盐混合后,经气流粉碎机粉碎,得到粉末;再与93.7%的石英砂和0.1%的聚乙烯醇水溶液混合均匀,烘干,得杀螺胺乙醇胺盐颗粒剂。所制得的颗粒剂为干燥、自由流动的黄色颗粒,无可见外来物和硬块,粉尘少,适于机器施药;堆密度、松密度和水分分别为1.4、1.3g/ml和2.4%,热储稳定性合格。实验室采用0.5 g/m25%杀螺胺乙醇胺盐颗粒剂喷撒7 d后,或>1.0 g/m2剂量喷撒1 d后,钉螺死亡率均>95%;现场采用0.5 g/m25%杀螺胺乙醇胺盐颗粒剂喷撒7 d后,或>1.0 g/m2剂量喷撒1 d后,钉螺死亡率均>85%。结论5%杀螺胺乙醇胺盐颗粒剂杀螺效果较好,是一种适合现场应用的新型杀螺剂型。
Objective To study the preparation method of 5% killer amine ethanolamine salt granules and its effect of killing snail. Methods The optimum formulation of 5% Spirotetramatine salt granules was obtained by screening wetting agent, dispersant, binder and carrier. The obtained niclosamide ethanolamine salt granules were evaluated for bulk density, bulk density, moisture content and thermal storage stability, and the laboratory and field snail killing effects of 5% schizandrine salt granules spraying method were investigated. Results The best formulation and preparation method of 5% killer amine ethanolamine salt granules were as follows: 5% spandex ethanolamine salt, 0.2% sodium dodecyl sulfate, 1% alkylphenol polyoxyethylene ether sulfonate After the acid salt is mixed, the mixture is crushed by a jet mill to obtain a powder; the mixture is further mixed with 93.7% of quartz sand and 0.1% of polyvinyl alcohol aqueous solution for drying to obtain the nutraceutical salt granules. The granules obtained were dry, free-flowing yellow granules with no visible foreign matter and lumps and little dust, suitable for machine application; the bulk density, bulk density and moisture were 1.4, 1.3 g / ml and 2.4% respectively, Thermal storage stability. In the laboratory, the death rate of Oncomelania snails was> 95% after sprayed with 0.5 g / m 25% spirotetramatine granules for 7 d or> 1.0 g / m 2 for 1 d respectively. On the spot, 0.5 g / m 25% Spirillum mortality was> 85% after 7 days spraying with spirotetramatine granules or spraying 1.0 g / m2 dose for 1 day. Conclusion 5% Spiroxamide ethanolamine granules kill snail better, is a suitable field application of a new type of narcotic.