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目的比较单片联合制剂(SPC)与自由联合治疗对高血压患者依从性的影响。方法将200例高血压患者随机分为观察组和对照组各100例。观察组给予厄贝沙坦/氢氯噻嗪片治疗,对照组给予厄贝沙坦片和氢氯噻嗪片治疗。2组患者每天接受药物的剂量和服药次数均相同。12个月后统计2组的依从性,测量治疗前后2组的收缩压、舒张压。结果观察组100例中因药物过敏退出试验1例,失访1例,剩余98例,对照组100例中因突发脑出血抢救无效死亡1例,剩余99例。随访12个月,观察组依从性明显优于对照组;2组患者经12个月治疗后血压水平均低于治疗前,且观察组血压水平明显低于对照组,差异均有统计学意义(P<0.05)。结论单片联合制剂能明显提高高血压患者的依从性,增加患者血压达标率。
Objective To compare the effects of single-agent combination (SPC) and free combination therapy on the compliance of hypertensive patients. Methods 200 cases of hypertensive patients were randomly divided into observation group and control group of 100 cases. The observation group was treated with irbesartan / hydrochlorothiazide tablets, while the control group was treated with irbesartan tablets and hydrochlorothiazide tablets. Patients in both groups received the same dose of medication and the same number of doses per day. After 12 months, the compliance of the two groups was calculated, and the systolic and diastolic blood pressures of the two groups were measured before and after treatment. Results In the observation group of 100 cases, 1 patient was withdrawn due to drug allergy, 1 patient was lost to follow-up, and the remaining 98 patients. In the control group, 1 patient died of sudden cerebral hemorrhage and 1 patient died. The remaining 99 patients. The follow-up of 12 months, the observation group was significantly superior to the compliance group; two groups of patients after 12 months of treatment were lower than before treatment, and the observation group of blood pressure was significantly lower than the control group, the differences were statistically significant P <0.05). Conclusion Monolithic combination can significantly improve the compliance of hypertensive patients and increase the blood pressure compliance rate.