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人羊膜细胞FL系含有低水平的基础EROD,ECOD和APND活性,其中EROD活性可被3—MC,β—NF及NE诱导达对照的3.1～6.7倍;ECOD和APND活性则不仅可被上述三种诱导剂还可被PB所诱导,分别增加到2～3和1.5～2倍的活性。当用3—MC与NE同时处理细胞时,EROD和APND活性的升高明显强于3—MC单独处理时。在诱导剂撤除后,细胞内EROD和ECOD的活性维持诱导后的高水平达24～36 h之久。提示诱导后一定时间内细胞对外来化合物的代谢能力明显增强。
FL in human amniotic cells contained low levels of basal EROD, ECOD and APND activity, of which EROD activity was 3.1- to 6.7-fold up-regulated by 3-MC, [beta] -FN and NE; ECOD and APND activities were not only inhibited by the above three Inducible agent can also be induced by PB, respectively, increased to 2 to 3 and 1.5 to 2 times the activity. When cells were treated simultaneously with 3-MC and NE, the EROD and APND activity was significantly increased over 3-MC alone. After the inducer was removed, intracellular EROD and ECOD activity remained high after induction for 24 to 36 h. Prompted after the induction of cells within a certain period of time the metabolism of foreign compounds increased significantly.