论文部分内容阅读
目的分析３６例药物性肝病的病因和临床特点，以加深临床医师对药物性肝病的认识。方法根据患者服药史、临床表现、血象、肝功能实验、血清标志以及停药后的效应作出综合判断。结果引起肝病的有关药物中，抗结核病药占２７．８％，解热镇痛抗炎药占２５％，抗肿瘤类药占８．３％，中草药类占８．３％，抗菌药占５．６％，抗真菌药占５．６％。其它类药包括性激素类、镇静催眠药、抗精神病药、抗癫痫药、降血糖药、抗甲状腺药。临床病理分型：３４例急性药物性肝病，其中肝细胞损伤型（包括肝炎型、脂肪肝型）２８例，胆汁淤积型２例，混合型４例；慢性药物性肝病２例。经停药后治疗，大部分病例痊愈，１例亚急性重症肝炎患者死亡。结论临床医师应重视药物性肝病的预防、诊断和治疗。
Objective To analyze the etiology and clinical features of 36 cases of drug-induced liver disease in order to deepen the understanding of clinicians on drug-induced liver disease. Methods According to the patients taking history, clinical manifestations, blood, liver function tests, serum markers and the effect of withdrawal after a comprehensive judgment. Results Among the related drugs that caused liver diseases, anti-TB drugs accounted for 27.8%, antipyretic and analgesic anti-inflammatory drugs 25%, anti-tumor drugs 8.3%, Chinese herbal medicines 8.3% and antibacterials 5 .6%, antifungal drugs accounted for 5.6%. Other classes of drugs include sex hormones, sedatives and hypnotics, antipsychotics, antiepileptics, hypoglycemic agents, anti-thyroid drugs. Clinicopathological type: 34 cases of acute drug-induced liver disease, including hepatocellular injury (including hepatitis type, fatty liver type) in 28 cases, 2 cases of cholestasis, mixed 4 cases; 2 cases of chronic drug-induced liver disease. After stopping treatment, the majority of cases were cured, 1 patient died of subacute severe hepatitis. Conclusion Clinicians should pay attention to the prevention, diagnosis and treatment of drug-induced liver disease.