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目的 探讨sVCAM 1、TNFα在过敏性紫癜 (HSP)发病中的临床意义。方法 采用固相酶联免疫分析 (ELISA)法检测 6 2例HSP患者血浆sVCAM 1、TNFα含量。结果 HSP急性期患者血浆sVCAM 1、TNFα较健康对照组明显升高 (P <0 0 1 ) ,而HSP缓解期患者与健康对照组间无显著差异 (P >0 0 5 ) ,且sVCAM 1与TNFα呈正相关。结论 sVCAM 1、TNFα可能参与HSP血管炎的发生发展过程 ,血浆sVCAM 1、TNFα检测有助于对HSP病情发展作出判断。
Objective To investigate the clinical significance of sVCAM 1 and TNFα in the pathogenesis of Henoch-Schonlein purpura (HSP). Methods The plasma levels of sVCAM 1 and TNFα in 62 patients with HSP were measured by enzyme-linked immunosorbent assay (ELISA). Results The plasma levels of sVCAM 1 and TNFα in patients with acute HSP were significantly higher than those in healthy controls (P <0.01), while there was no significant difference between HSP patients and healthy controls (P> 0.05) TNFα was positively correlated. Conclusion sVCAM 1 and TNFα may be involved in the pathogenesis of HSP vasculitis. The detection of plasma sVCAM 1 and TNFα may be useful for judging the development of HSP.