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目的观察胰岛素干预治疗对脑梗死合并糖耐量异常患者预后的影响。方法将87例脑梗死合并糖耐量异常患者随机分为治疗组45例和对照组42例,分别给予胰岛素干预治疗和常规治疗。治疗前、治疗后14d和治疗后28d,均用美国国立卫生院卒中评分(National Institutes Of Health Stroke Scale,NIHSS)评定患者的病情严重程度,用Barthel生活指数(Barthelindex,BI)评定患者的日常生活能力。结果治疗前两组NIHSS评分及Barthel指数积分相近,差异无显著性,治疗后(14d和28d),治疗组NIHSS评分较对照组显著降低(p<0.05)。治疗组的总有效率为80%,显著优于对照组的61.9%。结论胰岛素对于脑梗死合并糖耐量异常的缺血性脑损害有保护作用。
Objective To observe the effect of insulin intervention on the prognosis of patients with cerebral infarction and impaired glucose tolerance. Methods A total of 87 patients with cerebral infarction complicated with impaired glucose tolerance were randomly divided into treatment group (n = 45) and control group (n = 42), and were given insulin intervention and routine treatment respectively. Before treatment, 14 days after treatment and 28 days after treatment, the severity of the patients was assessed by the National Institutes of Health Stroke Scale (NIHSS). The Barthel index (Barthelindex, BI) was used to assess the patient’s daily life ability. Results The scores of NIHSS and Barthel index before treatment were similar between the two groups. There was no significant difference between the two groups after treatment (14d and 28d). The NIHSS score of the treatment group was significantly lower than that of the control group (p <0.05). The total effective rate of the treatment group was 80%, significantly better than the control group of 61.9%. Conclusion Insulin has a protective effect on cerebral infarction complicated with ischemic brain damage with impaired glucose tolerance.