本文报道古尼拟青霉毒性实验结果和对中枢神经系统的作用。古尼拟青霉干粉经口LD_(50)大于6g/kg;药液经口、皮下及腹腔LD_(50)均大于30/kg。亚慢性毒性实验大鼠进食含本品干粉1、2、3g/kg/d的饲料3个月,血常规、肝、肾功能及脏器的病理组织学检查无异常。本品对中枢神经系统有镇静、加强戊巴比妥钠作用及镇痛、降温等作用。 This article reports the results of the toxicity test of Paecilomyces pomonella and its effects on the central nervous system. The LD_(50) of Penicillium genioniani was greater than 6g/kg by oral administration, and the LD_(50) was greater than 30/kg by mouth, subcutaneous and abdominal cavity. Subchronic toxicity experiment rats fed diets containing 1,2,3 g/kg/d dry powder for 3 months. There were no abnormal histological examinations of blood routine, liver and kidney function and organs. This product has a sedative effect on the central nervous system, to enhance the role of pentobarbital sodium and analgesic, cooling and other effects.