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用Dig-McAb (digoxin-specific monoclonal antibody,地高辛单克隆抗体)Fab片段和IgG分别救治猴严重地高辛中毒成功。对照猴用无关McAb救治则短时内死于心室颤动。救治成活猴血清地高辛含量于Dig-McAb生效时,成倍增高且半衰期延长。Fab片段治疗后血中无相应抗抗体存在。表明Dig-McAb Fab片段是解除猴严重地高辛中毒之安全、速效而可靠的解毒剂。
Dig-McAb (digoxin-specific monoclonal antibody) Fab fragment and IgG were used to treat the success of severe digoxin poisoning in monkeys. Control monkey with irrelevant McAb died of ventricular fibrillation within a short time. Treatment of living monkeys Digoxigenin in Dig-McAb effective, doubled and extended half-life. There was no corresponding anti-antibody in the blood after Fab fragment treatment. This indicates that the Dig-McAb Fab fragment is a safe, fast and reliable antidote to rid the monkey of severe digoxin toxicity.