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动脉粥样硬化(以下简称动粥化)的病理特征除与管壁外部因子有关外,主要取决管壁固有的代谢特性。近年来关于决定管壁代谢特征的酶类变化和本病发生的关系,越来越受到人们重视。本文拟对本病最具特性的表现即胆固醇酯(CE)在动脉内膜沉积及其有关酶类变化,作一概述,并联系冠心病防治进行初步讨论。动粥化时动脉内膜CE的含量变化远溯Vischow时代,人们就注意到动粥化病变组织有大量胆固醇沉积。对比人和实验动物正常和病变血管脂质组成的化学分析结果,发现人、猴、兔、鸽等主动脉病变组织总胆固
The pathological features of atherosclerosis (hereinafter referred to as moving porridge) are mainly related to the intrinsic metabolic properties of the vessel wall except for the external factors of the vessel wall. In recent years, the relationship between the changes of enzymes that determine the metabolic characteristics of the tube wall and the occurrence of this disease has drawn more and more attention. This article intends to the most characteristic manifestation of the disease that cholesteryl ester (CE) in the arterial intimal deposition and related changes in enzymes, made an overview, and prevention and treatment of coronary heart disease in preliminary discussions. Moving porridge arterial endometrial CE content changes far back Vischow era, people noticed that there are a large number of porridge lesions of porridge with a large amount of cholesterol deposition. Comparison of human and experimental animal normal and diseased vascular lipid composition of chemical analysis results found that human, monkey, rabbit, pigeon and other aortic lesions total cholesterol