1例53岁男性患者,因咽炎给予克林霉素600 mg溶入0.9%氯化钠注射液250 ml静脉滴注。滴注结束时,患者突然昏迷,呼之不应,呼吸12次/min,双侧瞳孔对光反射消失。给予吸氧、补液治疗1 h后仍呈深昏迷状态。分别给予甘露醇、呋塞米、纳洛酮、葛根素、奥扎格雷钠等静脉滴注,治疗约12 h患者清醒,治疗约15 h时突然出现狂躁,给予氟哌啶醇5 mg肌内注射。治疗约20 h患者精神状态基本恢复正常。 A 53-year-old male patient was given an IV infusion of clindamycin 600 mg in 0.9% sodium chloride 250 ml for pharyngitis. At the end of instillation, the patient suddenly coma, call should not, breathing 12 times / min, bilateral pupil light reflex disappeared. Given oxygen, rehydration therapy 1 h still showed a deep coma state. Were given mannitol, furosemide, naloxone, puerarin, ozagrel sodium and other intravenous drip, the treatment of patients awake about 12 h, about 15 h treatment suddenly appeared manic, given haloperidol 5 mg intramuscularly injection. About 20 h treatment of patients with mental status returned to normal.