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应用巯甲丙脯酸与小剂量他巴唑联合治疗甲状腺功能亢进症(甲亢)92例(A 组),单用他巴唑92例作为对照(B 组)。结果:治疗1周时甲亢诊断指数正常者 A 组11例(12%),B 组无1例达到正常;治疗4周时,A 组正常者85例(92.4%),B 组仅53例(57.6%),经统计学处理,两组有非常显著性差异(P<0.001)。血清 T_3、T_4浓度变化:A 组从治疗后的第1周即明显下降(P<0.001),直至第4周;B组治疗的第1周无明显下降(P>0.05),第2周以后明显下降,但下降速度也不如 A 组快。表明巯甲丙脯酸加小剂量他巴唑能迅速缓解临床症状,降低血清 T_3、T_4浓度,改善甲状腺功能,疗效较单用他巴唑治疗为优。
Ninety-two patients (group A) with hyperthyroidism (hyperthyroidism) were treated with captopril combined with low-dose methimazole, and 92 patients treated with methimazole alone (group B). Results: In the first week of treatment, the diagnosis index of hyperthyroidism was normal in 11 cases (12%) in group A and no one in group B was normal. At 4 weeks, 85 cases (92.4%) were normal in group A and 53 cases in group B 57.6%). After statistical analysis, there was a significant difference between the two groups (P <0.001). Serum T_3 and T_4 concentrations in group A decreased significantly from the first week after treatment (P <0.001) until the fourth week, while there was no significant decrease in the first week after treatment (P> 0.05). After the second week Significant decline, but the decline is not as fast as A group. It shows that captopril and small dose of methimazole can quickly relieve clinical symptoms, reduce serum T_3, T_4 concentration and improve thyroid function.