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目的探讨术前纤维蛋白水平对结肠癌患者预后的预测价值,寻求结肠癌预后的新的预测指标。方法收集自2007年1月至2008年12月于我科就诊,并行根治性手术的结肠癌患者的临床资料。分别按照体重指数、肿瘤大小、分期、分化程度、大体分型、血管浸润情况、CEA水平、mGPS评分对患者进行分组,比较组间患者术前纤维蛋白水平的差异及术后生存情况的差异。结果本次研究共纳入结肠癌患者255例,患者的术前平均纤维蛋白水平为(3.17±0.88)g/L。不同肿瘤大小、分期、分化程度、大体分型、血管浸润情况、CEA、mGPS评分组患者术前纤维蛋白水平相比差异有统计学意义(P<0.05)。单因素分析结果显示术前纤维蛋白水平与结肠癌患者术后总体生存情况有关(P<0.05)。结论术前纤维蛋白水平与结肠癌患者临床病理特征有关,可作为预测患者预后的指标之一。
Objective To investigate the predictive value of preoperative fibrin levels in prognosis of patients with colon cancer and seek new prognostic indicators of colon cancer prognosis. Methods The clinical data of patients with colon cancer who underwent radical surgery in our department from January 2007 to December 2008 were collected. Patients were divided into groups according to body mass index, tumor size, stage, degree of differentiation, gross type, vascular infiltration, CEA level and mGPS score. Differences in preoperative fibrin levels and postoperative survival were compared among groups. Results A total of 255 patients with colon cancer were enrolled in this study. The average preoperative fibrin level was 3.17 ± 0.88 g / L. There were significant differences in the preoperative fibrin levels between different tumor sizes, stages, degree of differentiation, gross type, vascular infiltration, CEA and mGPS scores (P <0.05). Univariate analysis showed that preoperative fibrin levels were associated with overall postoperative survival in patients with colon cancer (P <0.05). Conclusions Preoperative fibrin levels are associated with the clinicopathological features of patients with colon cancer and may be used as an index to predict the prognosis of patients.