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目的 比较不同胰岛素给药方法对高血糖治疗差异。方法 2 6例需胰岛素治疗的高血糖病人住院进行了两种胰岛素强化治疗。⑴胰岛素泵连续皮下治疗 (CSⅡ组 :1型DM 4例 ,2型DM 2例 ) ;⑵多次皮下注射胰岛素治疗 (MSⅡ :1型DM 3例 ,2型DM 17例 )。二组治疗目标血糖值均为三餐前血糖及睡前末梢血糖≥3 6mmol/L且≤ 7 2mmol/L并至少 3d。结果 二组病人最终均达到了目标血糖值 ,但CSⅡ组更接近正常水平 ,平均高血糖控制天数有显著性差异。CSⅡ组 :(8 3± 1 3)d ,MSⅡ组 :(13 6± 2 4 )d ,(t =5 136,P <0 0 5 )。胰岛素用量无显著性差异。CSⅡ :(4 3 4± 8 4 )u/d ,MSⅡ :(4 7 2± 8 7)u/d ,(t =0 94 5 ,P >0 0 5 ) ,而CSⅡ组低血糖发生率低于MSⅡ组 ,CSⅡ :(0 67± 1 3)次 /人 ,MSⅡ :(2 15± 1 4 )次 /人 ,(t =2 30 5 ,P <0 0 5 )。结论 CSⅡ组可较MSⅡ组更快更有效控制高血糖 ,并减少低血糖发生
Objective To compare the differences in the treatment of hyperglycemia between different insulin administration methods. Twenty-six patients with hyperglycemia requiring insulin therapy were hospitalized for two intensive insulin treatments. Subcutaneous insulin pump treatment (CS Ⅱ group: type 1 DM 4 cases, type 2 DM 2 cases); (2) multiple subcutaneous injections of insulin therapy (MS Ⅱ: 1 type DM, 17 cases of type 2 DM). The blood glucose of the two groups were both before meals and before going to bed blood glucose ≥ 36mmol / L and ≤ 72mmol / L and at least 3d. Results The two groups of patients eventually reached the target blood glucose values, but the CS Ⅱ group was closer to normal levels, the average number of days of control of hyperglycemia were significantly different. CSⅡ group: (8 3 ± 1 3) d, MS Ⅱ group: (13 6 ± 2 4) d, (t = 5 136, P 0 05). There was no significant difference in insulin dosage. CSⅡ: (434 ± 8 4) u / d, MSⅡ: (472 ± 8 7) u / d, (t = 0 94 5, P> 0 05) In MSⅡ group, CSⅡwas (0 67 ± 1 3) times / person, MSⅡ: (2 15 ± 14) times / person, (t = 2 30 5, P 0 05). Conclusion CS Ⅱ group can control hyperglycemia faster and more effectively than MS Ⅱ group and reduce hypoglycemia