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目的探讨氯吡格雷和阿司匹林在脑梗死中的防治效果。方法 72例脑梗死患者,随机分为氯吡格雷组和阿司匹林组,各36例。两组均给予相同基础治疗,氯吡格雷组同时给予氯吡格雷,阿司匹林组给予阿司匹林治疗。评定两组患者治疗后不同时间神经功能缺损评分,观察治疗期间不良反应发生情况。结果氯吡格雷组和阿司匹林组治疗24周后神经功能缺损评分量表(NIHSS)评分分别低于本组治疗前与治疗后2、4、12周评分,差异均具有统计学意义(P<0.05)。氯吡格雷组治疗后2、4、12、24周评分和阿司匹林组比较,差异无统计学意义(P>0.05)。氯吡格雷组不良反应发生率为5.6%低于阿司匹林组的25.0%,差异有统计学意义(P<0.05)。结论氯吡格雷和阿司匹林在脑梗死防治中疗效近似,但氯吡格雷不良反应发生率低,值得借鉴。
Objective To investigate the prevention and treatment of clopidogrel and aspirin in cerebral infarction. Methods 72 patients with cerebral infarction were randomly divided into clopidogrel group and aspirin group, 36 cases each. Both groups were given the same basic treatment, clopidogrel group also given clopidogrel, aspirin group given aspirin treatment. The neurological deficit scores of the two groups were evaluated at different times after treatment, and the adverse reactions were observed during the treatment. Results After 24 weeks of treatment, the NIHSS score of clopidogrel group and aspirin group were lower than those of the two groups before treatment and 2,4,12 weeks after treatment (P <0.05, respectively) ). Clopidogrel group 2,4,12,24 weeks after treatment score and aspirin group, the difference was not statistically significant (P> 0.05). The incidence of adverse reactions in clopidogrel group was 5.6% lower than in aspirin group 25.0%, the difference was statistically significant (P <0.05). Conclusion Clopidogrel and aspirin have similar curative effect in the prevention and treatment of cerebral infarction, but the incidence of adverse reactions of clopidogrel is low, it is worth learning from.