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[目的]探讨人脑膜瘤中血管紧张素Ⅱ(AngⅡ)1型(AT1)和2型(AT2)受体的表达情况。[方法]采用免疫组化和RT-PCR方法,检测8例正常脑组织和31例人脑膜瘤组织中AngⅡ受体亚型蛋白及mRNA表达的变化。[结果]AT1和AT2受体在人脑瘤瘤细胞膜和细胞浆中均有表达。AT1受体蛋白和mRNA在脑膜瘤组织中有较高的表达水平,AT2受体在正常脑组织和脑膜瘤组织中的表达水平基本相似。[结论]AT1受体在人脑膜瘤生长中可能发挥更为重要作用,应用AT1拮抗剂对防治脑膜瘤可能有一定意义。
[Objective] To investigate the expression of angiotensin Ⅱ type 1 (AT1) and type 2 (AT2) receptors in human meningiomas. [Method] The expressions of AngⅡ receptor subtype protein and mRNA in 8 normal brain tissues and 31 human meningioma tissues were detected by immunohistochemistry and RT-PCR. [Results] The AT1 and AT2 receptors were expressed in both cell membrane and cytoplasm of human brain tumor. The expression of AT1 receptor protein and mRNA in meningioma tissue was higher than that in normal brain tissue and meningioma tissue. [Conclusion] The AT1 receptor may play a more important role in the growth of human meningioma. The application of AT1 antagonist may have certain significance in the prevention and treatment of meningioma.