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目的为临床准确评估ＧＦＲ提供一定依据。方法我们对３２例慢性肾脏病患者及５例正常志愿者，用９９ｍＴｃ－ＤＴＰＡ的清除率测定肾小球滤过率（Ｔｃ－ＧＦＲ），同时测定血尿素氮（ＢＵＮ），肌酐（Ｓｃｒ），２４小时肌酐清除率（２４ｈＣｃｒ）和采用Ｃｏｃｋｃｒｏｆｔ－Ｇａｕｌｔ公式计算肌酐清除率（Ｃｃｏｃｋｃｒｏｆｔ），并进行比较和分析。结果以上指标与Ｔｃ－ＧＦＲ均存在相关关系；它们检出Ｔｃ－ＧＦＲ下降的敏感性分别是５０％、５８％、６９％和８０％；２４ｈＣｃｒ和Ｃｃｏｃｋｃｒｏｆｔ与Ｔｃ－ＧＦＲ的相关性显著优于ＢＵＮ，Ｃｃｏｃｋｃｒｏｆｔ检出Ｔｃ－ＧＦＲ下降的敏感性显著优于ＢＵＮ。结论传统的指标除ＢＵＮ外均能一定程度地准确反映ＧＦＲ。９９ｍＴｃ－ＤＴＰＡ清除率可以准确，安全，有效地测定ＧＦＲ，适用于某些对ＧＦＲ精确性要求较高的情况。
Objective To provide a basis for clinical accurate assessment of GFR. Methods Thirty-two patients with chronic kidney disease and five normal volunteers were enrolled in this study. The glomerular filtration rate (Tc-GFR) was measured by clearance rate of 99mTc-DTPA. Blood urea nitrogen (BUN), creatinine 24 hour creatinine clearance rate (24hCcr) and calculated using Cockcroft-Gault formula creatinine clearance rate (Ccockcroft), and compared and analyzed. Results The above indexes were correlated with Tc-GFR. The sensitivity of detecting Tc-GFR was 50%, 58%, 69% and 80% respectively. The correlation between 24hccr, Ccockcroft and Tc-GFR was significantly better than that of BUN , Ccockcroft detected significantly lower sensitivity to Tc-GFR than BUN. CONCLUSION Traditional indicators, except for BUN, accurately reflect GFR to a certain extent. 99mTc-DTPA clearance can accurately, safely and effectively measure GFR, and is suitable for some situations that require high accuracy of GFR.