应用~(51)Cr释放试验研究了人脐血LAK细胞对K562细胞及Raji细胞的杀伤率,以及OK-432、干酪乳酸杆菌对脐血LAK细胞的调节作用。结果表明,rIL-2可诱导人脐血淋巴细胞产生LAK细胞活性,杀伤Raji细胞的能力由10%增至50%,对K562细胞的杀伤力也明显增强,统计学处理有显著意义。培养4天的LAK细胞杀伤力最强,杀伤率随效靶比例的增加而增强。OK-432及干酪乳酸杆菌均能增强rIL-2诱导的脐血LAK细胞的抗瘤活性。 The ~(51)Cr release assay was used to study the killing rate of human umbilical cord blood LAK cells against K562 cells and Raji cells, and the regulation of OK-432 and Lactobacillus casei on cord blood LAK cells. The results showed that rIL-2 could induce LAK cell activity in human umbilical cord blood lymphocytes, and the ability of killing Raji cells increased from 10% to 50%. The killing power of K562 cells was also significantly enhanced, and the statistical treatment was significant. The LAK cells cultured for 4 days had the strongest lethality, and the killing rate increased with the increase in the proportion of the target. Both OK-432 and Lactobacillus casei enhanced the antitumor activity of rIL-2 induced umbilical cord blood LAK cells.