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目的分析肺结核患者治疗过程中血清IL-10、IL-12p40、IL-12p70、IL-17A、IL-4、IL-6和IP10水平的动态变化,以进一步阐明这些因子与结核病发生发展的关联性。方法应用液相芯片技术检测59例成功治愈的初治菌阳肺结核患者治疗前、治疗2个月末和6个月末的血清IL-10、IL-12p40、IL-12p70、IL-17A、IL-4、IL-6和IP10水平,应用配对t检验分别比较各因子3个时点间的血清表达水平差异。结果 3个时间点血清IL-10、IL-12p40、IL-12p70、IL-17A、IL-4、IL-6和IP10水平(pg/m L):治疗前分别为1.71±0.91、5.02±11.53、2.48±11.03、1.12±0.46、0.36±1.87、8.99±7.82和882.74±1 110.73,治疗2个月末分别为2.39±1.47、8.95±13.76、1.77±1.80、0.96±0.22、0.51±1.11、4.75±4.16和408.38±492.27,治疗6个月末分别为1.84±0.93、5.14±10.16、1.59±0.78、0.79±0.22、0.44±0.48、4.05±4.51和177.57±104.83。治疗前与治疗2个月末及治疗6个月末的IL-6水平、治疗前与治疗2月末的IL-10和IL-12p40水平以及治疗前、治疗2个月末、6个月末的IL-17A和IP10水平均有显著性差异(P<0.05)。结论血清IL-17A、IP10、IL-6、IL-10和IL-12p40水平与结核病的发生发展存在密切关联。
Objective To analyze the dynamic changes of serum levels of IL-10, IL-12p40, IL-12p70, IL-17A, IL-4, IL-6 and IP10 during the treatment of patients with pulmonary tuberculosis to further elucidate the association between these factors and the occurrence and development of tuberculosis . Methods The serum level of IL-10, IL-12p40, IL-12p70, IL-17A and IL-4 in 59 newly diagnosed bacillary positive pulmonary tuberculosis patients before treatment, 2 months after treatment and 6 months after treatment were detected by liquid- , IL-6 and IP10 levels, the paired t-test was used to compare the serum levels of three factors at different time points. Results The levels of IL-10, IL-12p40, IL-12p70, IL-17A, IL-4, IL-6 and IP10 in serum at three time points before treatment were 1.71 ± 0.91,5.02 ± 11.53 , 2.48 ± 11.03,1.12 ± 0.46,0.36 ± 1.87,8.99 ± 7.82 and 882.74 ± 1107.73, respectively, at the end of the two months of treatment were 2.39 ± 1.47,8.95 ± 13.76,1.77 ± 1.80,0.96 ± 0.22,0.51 ± 1.11,4.75 ± 4.16 and 408.38 ± 492.27, respectively, at the end of 6 months of treatment were 1.84 ± 0.93, 5.14 ± 10.16, 1.59 ± 0.78, 0.79 ± 0.22, 0.44 ± 0.48, 4.05 ± 4.51 and 177.57 ± 104.83, respectively. The level of IL-6 before treatment and at the end of 2 months and the end of 6 months of treatment, the levels of IL-10 and IL-12p40 before treatment and at the end of treatment 2, and the levels of IL-17A at the end of 2 months, 6 months after treatment IP10 levels were significantly different (P <0.05). Conclusion Serum levels of IL-17A, IP10, IL-6, IL-10 and IL-12p40 are closely related to the occurrence and development of tuberculosis.